Int Arch Occup Environ Health. Epidermal membranes were set up in glass diffusion cells and, following an initial determination of permeability to tritiated water, excess undiluted glycol ether was applied to the outer surface for 8 hr. Diethylene glycol monoethyl ether (Transcutol ® P, TRC) seems to be very attractive as skin penetration enhancer due to its non-toxicity, biocompatibility, miscibility with polar and non-polar solvents . BACKGROUND A risk assessment of EGBE with the chemical name 2-butoxyethanol or ethylene glycol monobutyl ether was done by a member state (France).  |  To assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. For all solvents tested the lag time was less than 2 h, and for the majority of them was about 60 min. IDENTIFICATION MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. Liquid. All solvents were tested in their pure form and with 70% acetone. © 2017 Elsevier B.V. All rights reserved. eCollection 2018. Skin permeation was calculated using the Franz cell method with human skin. Skin designati on NIOSH TWA (ppm) NIOSH TWA (mg/m3) NIOSH STEL (ppm) NIOSH STEL (mg/m3) NIOSH Carcinog en PROPYLENE GLYCOL MONOMETHYL ETHER 100 360 150 540 Chemical Name ACGIH ACGIH ACGIH ACGIH Glycol Ether PM www.aglayne.com Page 5 of 9 GLYCOL ETHER DB 1. The risk assessment is based mainly on open scientific literature and on skin absorptions studies done by Industry. However, prolonged or excessive application can cause redness and itching to sensitive skin. 2-Butoxyethanol is an organic compound with the chemical formula BuOC 2 H 4 OH (Bu = CH 3 CH 2 CH 2 CH 2).This colorless liquid has a sweet, ether-like odor, as it derives from the family of glycol ethers, and is a butyl ether of ethylene glycol.As a relatively nonvolatile, inexpensive solvent, it is used in many domestic and industrial products because of its properties as a surfactant. Rinse skin with water or shower. As previously reported, the in vitro permeation studies indicate the nanosizing as a key factor in the dermal penetration of topically applied diclofenac. Objectives: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol ethers in vitro. Version 1.11 Revision Date: 09/05/2019. It has been suggested that TRC can lead to the formation of a cutaneous depot of topically applied drugs due to its ability to increase skin permeability. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. Ingestion If swallowed, seek medical advice immediately and show this . Most glycol ethers are water-soluble, biodegradable and only a few are considered toxic. 77, No. Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Never give anything by mouth to an unconscious person. In vitro evaluation of the efficacy of skin barrier creams and protective gloves on percutaneous absorption of industrial solvents. Download : Download high-res image (136KB)Download : Download full-size image. SDS Number: 100000002203 2 / 12 Glycol Ether EB. HK- GLE26 is used in skin care, baby care, shampoos, bath and shower products... view more. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Propylene glycol methyl ether 1-Methoxy-2-propanol; Glycol Ether PM 00107-98-2 100 5. 2018 Oct 31;13(10):e0205458. Glycol ethers may be used in any food-related application (such as coatings or printing inks) without regard to specific FDA regulations if subsequent processing steps, such as washing, drying, vaporizing, heating, purging, etc., are adequate to completely remove all traces of the solvent. We use cookies to help provide and enhance our service and tailor content and ads. 12 Skincare Ingredients You May Want to Avoid . The influence of diethylene glycol monoethyl ether on (trans)dermal delivery of diclofenac nanosuspensions was evaluated by in vitro studies using Franz diffusion cells and pig skin. 4. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents; Classified as not expected to be potentially toxic or harmful: Environment Canada Domestic Substance List: Classified as a low human health priority: Environment Canada Domestic Substance List Absorption of Some Glycol Ethers Through Human Skin in Vitro by Paul H. Dugard,* Michael Walker,* Susan J. Mawdsley' and Robert C. Scott* Tb assist evaluation of the hazards of skin contact with selected undiluted glycol ethers, their absorption across isolated human abdominal epidermis was measured in vitro. Would you like email updates of new search results? A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). Applications. The A 25 % aqueous PGBE solution or as neat were applied on rabbit and rat skin (ECETOC, 2005). OSHA formerly had an 8-hour TWA limit of 100 ppm for dipropylene glycol methyl ether (DPGME), with a skin notation. glycol monoethyl ether (DEGEE) in all cosmetic products, except products for oral hygiene and eye products at a concentrations up to 1.5% does not pose a risk to the health of the consumer, provided that the level of ethylene glycol in DEGEE used is < 0.2%. 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. Epub 2017 Sep 12. Who is it for? Transcutol has no positive effects on diclofenac nanosuspension skin penetration. P304, P340 . Jeen International . By continuing you agree to the use of cookies. After 4 h, skin reactions such as erythema, edema, scaliness, small wounds, desquamation and fissuring were observed at the site of application. Skin, Eyes, Nose, and Throat: Most glycol ethers are easily absorbed through your skin; thus, skin contact can be the major route of exposure. Epub 2002 Aug 27. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 06/21/2018 Revision date: 06/21/2018 Supersedes: 11/30/2017 Version: 2.1 06/21/2018 EN (English US) Page 1 SECTION 1: Identification 1.1. Nanosized diclofenac maintains the same polymorphic form of the bulk drug. H332 Harmful … H312 Harmful in contact with skin. H312 Harmful in contact with skin. In this work, the penetration enhancer diethylene glycol monoethyl ether was included in novel diclofenac acid nanocrystal formulations, developed using the wet media milling technique and Poloxamer 188 as stabilizer. Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. METHODS: Skin permeation was calculated using the Franz cell method with human skin. Experience with human exposure to ethylene glycol monomethyl ether has indicated that it can result in the appearance of immature leucocytes, monocytic anaemia, and neurological and behavioural changes. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. FIRE-FIGHTING MEASURES Extinguishing Media: Water fog, carbon dioxide, dry chemical, foam. The Glycols produced mild to severe ocular irritation when tested in rabbits, with Hexylene Glycol produc- ing the most severe irritation. On the basis of the available data and by analogy with diethylene glycol monobutyl ether, dermal exposure is assumed to pose no additional risk. ETHYLENE GLYCOL N-BUTYL ETHER may react with bases, aluminum and oxidizing materials. 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. In this work, the penetration enhancer diethylene glycol monoethyl ether was included in novel diclofenac acid nanocrystal formulations, developed using the wet media milling technique and Poloxamer 188 as … The amount of solvent passing through the skin was analysed with a gas chromatographic technique employing flame ionization detection. It is a high molecular weight, high purity synthetic polymer made from... view more. The invention discloses a preparation method of glycol ether. Schenk L, Rauma M, Fransson MN, Johanson G. PLoS One. Our results confirm the high percutaneous absorption of the GEs tested. Epub 2006 Nov 10. 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